Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.424


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX3hg19_v1_chr5_+_170736287_1707363690.412.0e-02Click!
TLX1hg19_v1_chr10_+_102891060_1028912970.309.6e-02Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_217560247 16.584 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr7_-_16844606 9.908 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chrX_-_133119475 9.707 GPC3
glypican 3
chr8_-_82395401 9.345 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr12_-_56106061 8.827 NM_001144997
ITGA7
integrin, alpha 7
chr15_-_65503786 8.812 NM_003613
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr17_+_77030471 8.442 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr1_-_153588789 8.284 NM_020672
S100A14
S100 calcium binding protein A14
chrX_+_99899162 8.271 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr20_+_56136136 8.179 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr8_+_144295067 8.097 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr1_-_151345156 8.066 NM_003944
SELENBP1
selenium binding protein 1
chrX_-_128788913 7.795 NM_017413
APLN
apelin
chrX_-_133119624 7.662 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr14_+_85996454 7.622 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_116165043 7.615 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr11_+_77774902 7.544 NM_003251
THRSP
thyroid hormone responsive
chr8_-_42065037 7.497 PLAT
plasminogen activator, tissue
chr7_+_116164838 7.256 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr5_+_38445577 7.209 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr6_-_46922533 7.098 NM_015234
GPR116
G protein-coupled receptor 116
chr19_+_46801632 7.076 NM_022462
NM_152796
HIF3A

hypoxia inducible factor 3, alpha subunit

chrX_+_2746810 7.052 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr7_+_116165089 7.033 CAV1
caveolin 1, caveolae protein, 22kDa
chr16_+_57406398 6.985 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr11_-_62457001 6.844 LRRN4CL
LRRN4 C-terminal like
chr17_-_66951381 6.762 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr16_+_222845 6.626 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr17_+_38599651 6.452 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr16_+_226678 6.369 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr17_-_74533623 6.253 NM_134268
CYGB
cytoglobin
chr17_-_4463816 6.221 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr8_-_80679897 6.187 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr10_+_88718287 6.176 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr1_-_153585504 6.091 NM_080388
S100A16
S100 calcium binding protein A16
chr11_+_74862031 6.031 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr12_+_13349716 5.883 EMP1
epithelial membrane protein 1
chr15_-_40213087 5.830 NM_007223
GPR176
G protein-coupled receptor 176
chr7_-_27187367 5.801 NM_024014
HOXA6
homeobox A6
chr14_+_85996512 5.768 FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_22766765 5.734 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr9_+_27109138 5.729 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr11_-_119211526 5.693 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr19_-_49258646 5.523 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr12_+_13349601 5.519 NM_001423
EMP1
epithelial membrane protein 1
chr19_+_46806855 5.499 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr14_+_24867926 5.429 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr22_-_24640850 5.407 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr8_-_42065193 5.309 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr9_+_6215785 5.290 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr1_+_185703470 5.196 NM_031935
HMCN1
hemicentin 1
chr14_+_95047792 5.168 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_+_12960793 5.156 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr19_+_15783827 5.150 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr12_+_13349720 5.124 EMP1
epithelial membrane protein 1
chr9_-_13279562 5.093 MPDZ
multiple PDZ domain protein
chrX_+_46937744 5.087 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr3_-_58563070 5.080 FAM107A
family with sequence similarity 107, member A
chr20_+_34742656 4.947 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chrX_+_46937807 4.872 RGN
regucalcin (senescence marker protein-30)
chr3_-_12200339 4.846 TIMP4
TIMP metallopeptidase inhibitor 4
chr16_-_28550324 4.670 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr17_+_7184978 4.618 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chrX_+_46937889 4.576 RGN
regucalcin (senescence marker protein-30)
chr2_-_218843541 4.562 TNS1
tensin 1
chr3_-_12200850 4.533 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_39407449 4.506 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr11_-_62457370 4.484 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr9_-_8733893 4.464 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr12_+_119616594 4.428 NM_014365
HSPB8
heat shock 22kDa protein 8
chr7_-_99573637 4.409 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr18_-_55470279 4.347 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr11_-_2159472 4.316 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_8815370 4.262 NM_003480
MFAP5
microfibrillar associated protein 5
chr5_+_148961035 4.236 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr11_+_114166534 4.152 NM_006169
NNMT
nicotinamide N-methyltransferase
chr9_-_33402505 4.130 NM_001170
AQP7
aquaporin 7
chr3_-_195306274 4.113 APOD
apolipoprotein D
chr19_-_41356193 4.105 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr22_+_33196801 4.093 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr8_+_55370494 4.044 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr6_-_39197225 4.014 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr11_+_61976139 4.008 NM_002407
SCGB2A1
secretoglobin, family 2A, member 1
chr9_-_112970412 3.999 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr1_-_22263676 3.956 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr9_+_102584136 3.913 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr7_-_120498128 3.865 NM_012338
TSPAN12
tetraspanin 12
chr1_-_153599969 3.804 NM_001024211
S100A13
S100 calcium binding protein A13
chr1_-_161168816 3.711 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr16_+_20420854 3.677 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr21_+_46875402 3.633 NM_030582
COL18A1
collagen, type XVIII, alpha 1
chr1_+_220701547 3.633 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_+_43735664 3.633 NM_144626
TMEM125
transmembrane protein 125
chr1_+_22979681 3.616 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr6_+_132129154 3.603 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr4_-_142054431 3.593 NM_020724
RNF150
ring finger protein 150
chr9_-_132515290 3.583 NM_004878
PTGES
prostaglandin E synthase
chr10_+_124320180 3.581 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chrX_+_106171328 3.545 CLDN2
claudin 2
chr13_+_98795410 3.523 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr1_-_153600714 3.497 NM_005979
S100A13
S100 calcium binding protein A13
chr20_-_60942300 3.476 NM_005560
LAMA5
laminin, alpha 5
chr5_+_150020201 3.470 NM_001109974
NM_007286
SYNPO

synaptopodin

chr15_-_68724434 3.470 NM_001004439
ITGA11
integrin, alpha 11
chr9_-_34710062 3.465 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr17_-_15164043 3.437 NM_153322
PMP22
peripheral myelin protein 22
chr1_-_16344438 3.427 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr20_-_6034617 3.389 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr13_+_98795468 3.382 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr17_-_46671043 3.376 NM_002147
HOXB5
homeobox B5
chr19_-_33716609 3.372 NM_019849
SLC7A10
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
chr2_-_216300444 3.362 FN1
fibronectin 1
chrX_+_99899388 3.344 SRPX2
sushi-repeat containing protein, X-linked 2
chr16_-_86542463 3.321 LOC400550
uncharacterized LOC400550
chr17_-_76975932 3.306 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr20_+_42194736 3.305 NM_016276
SGK2
serum/glucocorticoid regulated kinase 2
chr19_+_36157714 3.283 NM_007000
UPK1A
uroplakin 1A
chr16_-_52581713 3.195 NM_001146188
TOX3
TOX high mobility group box family member 3
chr10_+_82173574 3.176 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr7_+_22767101 3.167 IL6
interleukin 6 (interferon, beta 2)
chr14_-_76447323 3.147 TGFB3
transforming growth factor, beta 3
chr1_-_160854869 3.142 NM_017625
ITLN1
intelectin 1 (galactofuranose binding)
chr9_-_130616957 3.082 ENG
endoglin
chrX_+_106161589 3.076 NM_001171095
CLDN2
claudin 2
chr3_-_50340979 3.074 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr9_+_136399877 3.047 NM_014694
ADAMTSL2
ADAMTS-like 2
chr14_-_76447445 3.024 TGFB3
transforming growth factor, beta 3
chr19_-_39523132 3.014 NM_178820
FBXO27
F-box protein 27
chr5_+_176516550 3.011 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr18_-_5892102 3.004 NM_001080209
TMEM200C
transmembrane protein 200C
chr11_-_6341708 2.962 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr16_-_19896105 2.951 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr11_+_74870824 2.919 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr11_-_2016743 2.915 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr9_-_130616592 2.909 ENG
endoglin
chr1_+_33231227 2.894 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr5_-_148758787 2.890 NM_014443
IL17B
interleukin 17B
chr12_-_8815479 2.869 MFAP5
microfibrillar associated protein 5
chr10_+_135160843 2.847 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr14_+_95047758 2.837 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr3_-_149421059 2.827 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chrX_+_134124967 2.827 NM_001163438
CXorf69
chromosome X open reading frame 69
chr1_+_201979689 2.825 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr14_-_76447235 2.816 TGFB3
transforming growth factor, beta 3
chr7_+_102553343 2.807 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr21_+_33784751 2.804 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr1_+_162602198 2.802 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr2_+_220325533 2.799 NM_001173476
SPEG
SPEG complex locus
chr1_-_23810627 2.796 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr14_-_76448091 2.777 NM_003239
TGFB3
transforming growth factor, beta 3
chr17_-_39661803 2.735 NM_002274
NM_153490
KRT13

keratin 13

chr22_+_30792929 2.727 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr9_-_33402463 2.723 AQP7
aquaporin 7
chr1_-_153599743 2.711 NM_001024212
S100A13
S100 calcium binding protein A13
chr19_-_35633354 2.703 LGI4
leucine-rich repeat LGI family, member 4
chr12_-_8815266 2.701 MFAP5
microfibrillar associated protein 5
chr14_+_95047730 2.613 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr14_+_96858436 2.590 NM_152327
AK7
adenylate kinase 7
chr8_-_22785228 2.589 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chrX_+_152770083 2.588 BGN
biglycan
chr1_+_153600859 2.585 NM_006271
S100A1
S100 calcium binding protein A1
chr9_-_130617009 2.575 NM_000118
NM_001114753
ENG

endoglin

chr20_+_9049660 2.573 NM_001172646
PLCB4
phospholipase C, beta 4
chr1_+_95558072 2.522 NM_001199679
TMEM56
transmembrane protein 56
chr17_+_37894212 2.516 GRB7
growth factor receptor-bound protein 7
chrX_-_13956445 2.516


chr9_-_130616760 2.510 ENG
endoglin
chr20_+_56725982 2.491 NM_178456
C20orf85
chromosome 20 open reading frame 85
chr21_+_47531369 2.490 COL6A2
collagen, type VI, alpha 2
chr12_+_16506350 2.476 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr10_+_5454516 2.460 NM_001047160
NET1
neuroepithelial cell transforming 1
chr1_-_153538305 2.455 NM_005978
S100A2
S100 calcium binding protein A2
chr1_+_203595897 2.421 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr1_-_23810721 2.414 NM_001143778
NM_017707
ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

chrX_+_13587693 2.411 NM_001167890
NM_015507
EGFL6

EGF-like-domain, multiple 6

chr4_+_183245136 2.410 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr8_-_81787015 2.394 NM_001033723
ZNF704
zinc finger protein 704
chr8_-_12973752 2.386 NM_001164271
DLC1
deleted in liver cancer 1
chr12_+_7169192 2.382


chr6_+_31982538 2.378 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr3_-_48471401 2.375 NM_001130082
PLXNB1
plexin B1
chr2_-_228582698 2.370 NM_025243
SLC19A3
solute carrier family 19, member 3
chr16_-_28550227 2.364 NUPR1
nuclear protein, transcriptional regulator, 1
chr22_+_40390935 2.343 NM_138435
FAM83F
family with sequence similarity 83, member F
chr14_-_61190458 2.332 NM_017420
SIX4
SIX homeobox 4
chr12_+_124773709 2.311 NM_181709
FAM101A
family with sequence similarity 101, member A
chr20_-_44168128 2.310 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr11_-_57089670 2.244 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr2_-_233877920 2.220 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr10_+_106034886 2.211 NM_001191014
NM_001191015
GSTO2

glutathione S-transferase omega 2

chr17_-_41910439 2.209 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr9_-_95244750 2.196 NM_001193335
NM_017680
ASPN

asporin

chr1_-_161059353 2.191 NM_030916
PVRL4
poliovirus receptor-related 4
chr6_+_132129195 2.147 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr9_+_74764266 2.139 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr8_-_13133956 2.136


chr22_-_31536339 2.130 NM_015715
PLA2G3
phospholipase A2, group III
chr8_-_21988518 2.100 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr1_+_101185195 2.099 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr11_+_6260321 2.095 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.84 3.62e-06 GO:0048856 anatomical structure development
1.73 6.69e-06 GO:0032502 developmental process
1.86 1.67e-05 GO:0048731 system development
1.72 5.65e-05 GO:0007275 multicellular organismal development
2.15 4.12e-04 GO:0009653 anatomical structure morphogenesis
1.48 8.20e-04 GO:0032501 multicellular organismal process
1.91 2.70e-03 GO:0048513 organ development
1.32 4.11e-03 GO:0065007 biological regulation
2.54 5.01e-03 GO:0007155 cell adhesion
2.54 5.01e-03 GO:0022610 biological adhesion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.21 1.33e-22 GO:0044421 extracellular region part
2.95 4.66e-21 GO:0005576 extracellular region
3.94 1.93e-14 GO:0005615 extracellular space
5.48 2.98e-13 GO:0031012 extracellular matrix
5.68 6.69e-12 GO:0005578 proteinaceous extracellular matrix
1.91 2.66e-05 GO:0044459 plasma membrane part
2.19 1.75e-04 GO:0031226 intrinsic to plasma membrane
2.18 2.68e-04 GO:0005887 integral to plasma membrane
5.83 5.09e-04 GO:0044420 extracellular matrix part
3.28 6.03e-04 GO:0009986 cell surface
7.65 2.12e-02 GO:0031093 platelet alpha granule lumen
7.49 2.39e-02 GO:0034774 secretory granule lumen
5.99 2.80e-02 GO:0005604 basement membrane
7.19 3.01e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
6.91 3.75e-02 GO:0031983 vesicle lumen
3.41 3.94e-02 GO:0045177 apical part of cell

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
8.24 2.31e-05 GO:0005201 extracellular matrix structural constituent
2.20 2.66e-03 GO:0005102 receptor binding
2.50 1.02e-02 GO:0005198 structural molecule activity
4.28 1.49e-02 GO:0030414 peptidase inhibitor activity
3.91 1.68e-02 GO:0061134 peptidase regulator activity
5.04 2.02e-02 GO:0019838 growth factor binding
25.67 4.06e-02 GO:0034713 type I transforming growth factor beta receptor binding
4.11 4.58e-02 GO:0004866 endopeptidase inhibitor activity