Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.424


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX3hg19_v1_chr5_+_170736287_1707363690.412.0e-02Click!
TLX1hg19_v1_chr10_+_102891060_1028912970.309.6e-02Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_217560247 16.584 NM_000599
 IGFBP5
insulin-like growth factor binding protein 5
chr7_-_16844606 9.908 NM_006408
 AGR2
anterior gradient 2 homolog (Xenopus laevis)
chrX_-_133119475 9.707 GPC3
glypican 3
chr8_-_82395401 9.345 NM_001442
 FABP4
fatty acid binding protein 4, adipocyte
chr12_-_56106061 8.827 NM_001144997
 ITGA7
integrin, alpha 7
chr15_-_65503786 8.812 NM_003613
 CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr17_+_77030471 8.442 NM_198593
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr1_-_153588789 8.284 NM_020672
 S100A14
S100 calcium binding protein A14
chrX_+_99899162 8.271 NM_014467
 SRPX2
sushi-repeat containing protein, X-linked 2
chr20_+_56136136 8.179 NM_002591
 PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr8_+_144295067 8.097 NM_178172
 GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr1_-_151345156 8.066 NM_003944
 SELENBP1
selenium binding protein 1
chrX_-_128788913 7.795 NM_017413
 APLN
apelin
chrX_-_133119624 7.662 NM_001164617
NM_001164618
NM_001164619
NM_004484
 GPC3



glypican 3



chr14_+_85996454 7.622 NM_013231
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_116165043 7.615 NM_001172895
 CAV1
caveolin 1, caveolae protein, 22kDa
chr11_+_77774902 7.544 NM_003251
 THRSP
thyroid hormone responsive
chr8_-_42065037 7.497 PLAT
plasminogen activator, tissue
chr7_+_116164838 7.256 NM_001753
 CAV1
caveolin 1, caveolae protein, 22kDa
chr5_+_38445577 7.209 NM_182801
 EGFLAM
EGF-like, fibronectin type III and laminin G domains

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
2.54 5.01e-03 GO:0007155 cell adhesion
2.54 5.01e-03 GO:0022610 biological adhesion
2.15 4.12e-04 GO:0009653 anatomical structure morphogenesis
1.91 2.70e-03 GO:0048513 organ development
1.86 1.67e-05 GO:0048731 system development
1.84 3.62e-06 GO:0048856 anatomical structure development
1.73 6.69e-06 GO:0032502 developmental process
1.72 5.65e-05 GO:0007275 multicellular organismal development
1.48 8.20e-04 GO:0032501 multicellular organismal process
1.32 4.11e-03 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
Enrichment   P-value GO Accession GO Term
7.65 2.12e-02 GO:0031093 platelet alpha granule lumen
7.49 2.39e-02 GO:0034774 secretory granule lumen
7.19 3.01e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
6.91 3.75e-02 GO:0031983 vesicle lumen
5.99 2.80e-02 GO:0005604 basement membrane
5.83 5.09e-04 GO:0044420 extracellular matrix part
5.68 6.69e-12 GO:0005578 proteinaceous extracellular matrix
5.48 2.98e-13 GO:0031012 extracellular matrix
4.21 1.33e-22 GO:0044421 extracellular region part
3.94 1.93e-14 GO:0005615 extracellular space
3.41 3.94e-02 GO:0045177 apical part of cell
3.28 6.03e-04 GO:0009986 cell surface
2.95 4.66e-21 GO:0005576 extracellular region
2.19 1.75e-04 GO:0031226 intrinsic to plasma membrane
2.18 2.68e-04 GO:0005887 integral to plasma membrane
1.91 2.66e-05 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
Enrichment   P-value GO Accession GO Term
25.67 4.06e-02 GO:0034713 type I transforming growth factor beta receptor binding
8.24 2.31e-05 GO:0005201 extracellular matrix structural constituent
5.04 2.02e-02 GO:0019838 growth factor binding
4.28 1.49e-02 GO:0030414 peptidase inhibitor activity
4.11 4.58e-02 GO:0004866 endopeptidase inhibitor activity
3.91 1.68e-02 GO:0061134 peptidase regulator activity
2.50 1.02e-02 GO:0005198 structural molecule activity
2.20 2.66e-03 GO:0005102 receptor binding